Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kinome Profiling of Chondrosarcoma Reveals Src-Pathway Activity and Dasatinib as Option for Treatment

14 Jul 2009

Abstract excerpt

Chondrosarcomas are notorious for their resistance to conventional chemotherapy and radiotherapy, indicating there are no curative treatment possibilities for patients with inoperable or metastatic disease. We therefore explored the existence of molecular targets for systemic treatment of chondrosarcoma using kinome profiling. Peptide array was performed for four chondrosarcoma cell lines and nine primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Myeloid Leukemia Treatments
Share to Multiple Myeloma Research and Treatments
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19602594
DOI: 10.1158/0008-5472.can-08-4801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinome Profiling of Chondrosarcoma Reveals Src-Pathway Activity and Dasatinib as Option for TreatmentPMID 19602594Read ↗

Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells.Semantic proximity Read ↗

Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.Semantic proximity Read ↗

Novel therapeutic approaches in chondrosarcoma.Semantic proximity Read ↗

Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma.Semantic proximity Read ↗

Molecular oncogenesis of chondrosarcoma: impact for targeted treatmentSemantic proximity Read ↗

Chondrosarcoma Organoids Reveal Targetable SHH Pathway Activation via PTCH1 AlterationsSemantic proximity Read ↗

Frequent activation of EGFR in advanced chordomasSemantic proximity Read ↗

Exploring the Role of CD44 in the Progression and Invasion of ChondrosarcomaSemantic proximity Read ↗

Genomic Characterization of Chondrosarcoma Reveals Potential Therapeutic TargetsSemantic proximity Read ↗

Trp53 and Rb1 deficiency in chondrocytes spontaneously develop chondrosarcoma by activation of YAP signalingSemantic proximity Read ↗

SRC: A Century of Science Brought to the ClinicSemantic proximity Read ↗

Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So FarSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.