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Article

The role of YY1 in reduced HP1alpha gene expression in invasive human breast cancer cells.

Breast cancer research : BCR - 1 Jan 2009

Lieberthal Jason G, Kaminsky Marissa, Parkhurst Christopher N, Tanese Naoko

Abstract excerpt

INTRODUCTION: Heterochromatin protein 1 (HP1) associates with chromatin by binding to histone H3 and contributes to gene silencing. There are three isoforms of HP1 in mammals: HP1alpha, beta, and gamma. Studies have shown that the level of HP1alpha is reduced in invasive human breast cancer cell lines such as MDA-MB-231 and HS578T compared with non-invasive cell lines such as MCF7 and T47D. It is hypothesized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19566924
DOI: 10.1186/bcr2329
PMCID: PMC2716511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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