Article
Down-regulation of HP1Hsalpha expression is associated with the metastatic phenotype in breast cancer.
Cancer research - 1 Jul 2000
Kirschmann D A, Lininger R A, Gardner L M, Seftor E A, Odero V A, Ainsztein A M, Earnshaw W C, Wallrath L L, Hendrix M J
Abstract excerpt
We previously identified a down-regulation in heterochromatin-associated protein 1 (HP1)Hsalpha expression in MDA-MB-231 breast carcinoma cells (highly invasive/metastatic) compared with MCF-7 cells (poorly invasive/nonmetastatic). In this study, we demonstrate that HP1Hsalpha, but not HP1Hsbeta or HP1Hsgamma, is down-regulated at the mRNA and protein levels in highly invasive/metastatic breast cancer cell lines....
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