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Prevention of PERV Infections in Pig to Human Xenotransplantation by the RNA Interference Silences Gene

1 Apr 2005

Abstract excerpt

The possibility of preventing the transmission of porcine endogenous retrovirus (PERV) to human cells using short interfering RNAs (siRNA) was investigated. The siRNA for the p30 of PERV gag region was cloned into pSUPER, the polymerase-III H1-RNA gene promoter. A green fluorescence protein (GFP) was also cloned into pSUPER to establish pSXGH. Pig endothelial cells (PEC) were transduced with the LacZ gene by...

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PMID: 15858174
DOI: 10.1093/jb/mvi059

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