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Article

Long‐term effects of PERV‐specific RNA interference in transgenic pigs

1 Mar 2012

Abstract excerpt

BACKGROUND: Porcine endogenous retroviruses (PERVs) represent a risk of xenotransplantation using porcine cells, tissues, or organs, as they are integrated in the porcine genome and have been shown to be able to infect human cells in vitro. To increase viral safety by RNA interference, transgenic pigs expressing a PERV-specific small hairpin (sh)RNA targeted to a highly conserved sequence in the pol gene (pol2)...

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PMID: 22497513
DOI: 10.1111/j.1399-3089.2012.00683.x

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