Article
Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis.
Nature communications - 17 Aug 2021
Wu Xunyao, Liu Yi, Jin Shanzhao, Wang Min, Jiao Yuhao, Yang Bo, Lu Xin, Ji Xin, Fei Yunyun, Yang Huaxia, Zhao Lidan, Chen Hua, Zhang Yaran, Li Hao, Lipsky Peter E, Tsokos George C, Bai Fan, Zhang Xuan
Abstract excerpt
The presence or absence of anti-citrullinated peptide antibodies (ACPA) and associated disparities in patients with rheumatoid arthritis (RA) implies disease heterogeneity with unknown diverse immunopathological mechanisms. Here we profile CD45+ hematopoietic cells from peripheral blood or synovial tissues from both ACPA+ and ACPA- RA patients by single-cell RNA sequencing and identify subsets of immune cells...
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