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Article

Aurora kinase targeting in lung cancer reduces KRAS-induced transformation.

Molecular cancer - 3 Feb 2016

Dos Santos Edmilson Ozorio, Carneiro-Lobo Tatiana Correa, Aoki Mateus Nobrega, Levantini Elena, Bassères Daniela Sanchez

Abstract excerpt

BACKGROUND: Activating mutations in KRAS are prevalent in lung cancer and have been causally linked to the oncogenic process. However, therapies targeted to oncogenic RAS have been ineffective to date and identification of KRAS targets that impinge on the oncogenic phenotype is warranted. Based on published studies showing that mitotic kinases Aurora A (AURKA) and B (AURKB) cooperate with oncogenic RAS to promote...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26842935
DOI: 10.1186/s12943-016-0494-6
PMCID: PMC4739397

Genes

KRAS
AURKA
AURKB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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