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Article

Role of p53 in the Regulation of Cellular Senescence

8 Mar 2020

Abstract excerpt

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle arrest that has a crucial role in aging, and it also represents a robust physiological antitumor response, which...

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PMID: 32182711
DOI: 10.3390/biom10030420

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