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Article

No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue.

Molecular cancer - 6 Nov 2009

Prokunina-Olsson Ludmila, Hall Jennifer L

Abstract excerpt

A single nucleotide polymorphism (SNP) rs6983267, located within the 8q24 region, is strongly associated with risk of colorectal and prostate cancer. It has been suggested that the mechanism of this association is related to differential interaction of TCF7L2 protein (previously known as TCF-4) w...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19895682
DOI: 10.1186/1476-4598-8-96
PMCID: PMC2777153

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19895682-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 11 closest

No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue.PMID 19895682Read ↗

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.Semantic proximity Read ↗

Gene variants of TCF7L2 are histopathologically important in colorectal cancers but do not have direct association with MYC expression.Semantic proximity Read ↗

Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.Semantic proximity Read ↗

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.Semantic proximity Read ↗

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.Semantic proximity Read ↗

Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer.Semantic proximity Read ↗

Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.Semantic proximity Read ↗

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.Semantic proximity Read ↗

Functional and clinical significance of variants localized to 8q24 in colon cancer.Semantic proximity Read ↗

Long-range enhancers on 8q24 regulate c-Myc.Semantic proximity Read ↗

The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines.Semantic proximity Read ↗

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