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Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA.

Human molecular genetics - 15 Sept 2009

Malena Adriana, Loro Emanuele, Di Re Miriam, Holt Ian J, Vergani Lodovica

Abstract excerpt

Biased segregation of mitochondrial DNA variants has been widely documented, but little was known about its molecular basis. We set out to test the hypothesis that altering the balance between mitochondrial fusion and fission could influence the segregation of mutant and wild-type mtDNA variants, because it would modify the number of organelles per cell. Therefore human cells heteroplasmic for the pathological...

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PMID: 19561330
DOI: 10.1093/hmg/ddp281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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