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Article

Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2009

Nichol Kathryn, Deeny Sean P, Seif Joseph, Camaclang Kevin, Cotman Carl W

Abstract excerpt

BACKGROUND: Human studies on exercise, cognition, and apolipoprotein E (APOE) genotype show that epsilon4 carriers may benefit from regular physical activity. METHODS: We examined voluntary wheel-running, memory, and hippocampal plasticity in APOE epsilon3 and APOE epsilon4 transgenic mice at 10-12 months of age. RESULTS: Sedentary epsilon4 mice exhibited deficits in cognition on the radial-arm water maze (RAWM),...

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Share to Apolipoprotein E3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19560099
DOI: 10.1016/j.jalz.2009.02.006
PMCID: PMC4105011

Genes

APOE
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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