Article
A predicted functional single-nucleotide polymorphism of bone morphogenetic protein-4 gene affects mRNA expression and shows a significant association with cutaneous melanoma in Southern Italian population.
Journal of cancer research and clinical oncology - 1 Dec 2009
Capasso Mario, Ayala Fabrizio, Russo Roberta, Avvisati Rosa Anna, Asci Roberta, Iolascon Achille
Abstract excerpt
PURPOSE: An altered expression of bone morphogenetic protein 4 (BMP4) has been found in malignant melanoma cells. We performed an association study to investigate the effect of putative functional single nucleotide polymorphisms (SNPs) of BMP4 on development of cutaneous melanoma (CM). METHODS: We selected the predicted functional SNPs 6007 C/T (rs17563) and -3445 T/G (rs4898820) by the combination of three...
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