Article
Associations of polymorphisms in the bone morphogenetic protein-2 gene with risk and prognosis of osteosarcoma in a Chinese population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Mar 2015
Cong Yu, Li Cheng-Jun, Zhao Jian-Ning, Liu Xiao-Zhou, Shi Xin
Abstract excerpt
Osteosarcoma is the most common type of bone cancer in adolescence. Bone morphogenetic protein-2 (BMP-2) plays important roles in the development of bone and cartilage and in inhibiting the tumorigenicity of cancer stem cells in human osteosarcoma cell line. The aim of this study was to examine whether polymorphisms in the BMP2 gene are associated with osteosarcoma risk and prognosis in Chinese population. Five...
Topics
- Adolescent
- Adult
- Aged
- Asian People
- Bone Morphogenetic Protein 2
- Bone Neoplasms
- Case-Control Studies
- Child
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Male
- Middle Aged