Article
Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
Pigment cell & melanoma research - 1 May 2013
Qian Ji, Liu Hongliang, Wei Sheng, Liu Zhensheng, Li Yangkai, Wang Li-E, Chen Wei V, Amos Christopher I, Lee Jeffrey E, Iles Mark M, Law Matthew H, Cust Anne E, Barrett Jennifer H, Montgomery Grant W, Taylor John, Bishop Julia A Newton, Macgregor Stuart, Bishop D Timothy, Mann Graham J, Hayward Nicholas K, Wei Qingyi
Abstract excerpt
To mine possibly hidden causal single-nucleotide polymorphisms (SNPs) of melanoma, we investigated the association of SNPs in 76 M/G1 transition genes with melanoma risk using our published genome-wide association study (GWAS) data set with 1804 melanoma cases and 1026 cancer-free controls. We found multiple SNPs with P < 0.01 and performed validation studies for 18 putative functional SNPs in PSMB9 in two other...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.