Article
Association of polymorphism of estrogen receptor-alpha gene with circulating levels of adiponectin in postmenopausal women with type 2 diabetes.
Journal of atherosclerosis and thrombosis - 1 Jun 2009
Yoshihara Rie, Utsunomiya Kazunori, Gojo Atsushi, Ishizawa Sho, Kanazawa Yasushi, Matoba Keiichiro, Taniguchi Kanta, Yokota Tamotsu, Kurata Hideaki, Yokoyama Jun-Ichi, Urashima Mitsuyoshi, Tajima Naoko
Abstract excerpt
AIM: Menopause is a risk factor for cardiovascular disease (CVD) in women because of the reduction in endogenous estrogen. Recently, single nucleotide polymorphisms (SNPs) of the estrogen receptor alpha (ESR-1) gene (c.454-397T>C) associated with the prognosis of myocardial infarction in postmenopausal women were identified; however, the mechanism by which genetic variation of ESR-1 contributes to the...
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