Article
Estrogen receptor 1 gene polymorphisms are associated with metabolic syndrome in postmenopausal women in China.
BMC endocrine disorders - 14 Sept 2018
Zhao Lingxia, Fan Xuemei, Zuo Lin, Guo Qiang, Su Xiaole, Xi Guangxia, Zhang Ziyan, Zhang Jianlin, Zheng Guoping
Abstract excerpt
BACKGROUND: Metabolic syndrome (MetS) includes obesity, diabetes, dyslipidemia and hypertension. Its incidence is rapidly increasing worldwide, particularly in postmenopausal women. Estrogens regulate glucose homeostasis and lipid metabolism via estrogen receptors 1 (ESR1) and 2 (ESR2). The current study aimed to elucidate associations of MetS with ESR1 and ESR2 gene polymorphisms in postmenopausal Chinese women....
Topics
- Aged
- Case-Control Studies
- China
- Estrogen Receptor alpha
- Female
- Genetic Predisposition to Disease
- Humans
- Metabolic Syndrome
- Middle Aged
- Polymorphism, Single Nucleotide