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Article

Normal fertility in male mice with deletion of β‐catenin gene in germ cells

20 Jan 2014

Abstract excerpt

As a dual function protein, β-catenin affects both cell adhesion and mediates canonical Wnt/β-catenin cell signaling. β-Catenin is prominently expressed in somatic Sertoli cells in the testis and postmeiotic germ cells, suggesting an additional role in spermatogenesis. It was reported previously that Cre/loxP-mediated conditional inactivation of the β-catenin gene (Ctnnb1) in male gonads using a protamine...

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PMID: 24443144
DOI: 10.1002/dvg.22742

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