Article
The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis.
Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006
Gao Fei, Maiti Sourindra, Alam Nargis, Zhang Zhen, Deng Jian Min, Behringer Richard R, Lécureuil Charlotte, Guillou Florian, Huff Vicki
Abstract excerpt
Mutation of the transcription factor and tumor suppressor gene WT1 results in a range of genitourinary anomalies in humans, including 46,XY gonadal dysgenesis, indicating that WT1 plays a critical role in sex determination. However, because knockout of Wt1 in mice results in apoptosis of the genital ridge, it is unknown whether WT1 is required for testis development after the initial steps of sex determination....
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