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Article

Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis.

Biology of reproduction - 1 Feb 2010

Tanwar Pradeep S, Kaneko-Tarui Tomoko, Zhang LiHua, Rani Poonam, Taketo Makoto M, Teixeira Jose

Abstract excerpt

Sertoli and germ cell interactions are essential for spermatogenesis and, thus, male fertility. Sertoli cells provide a specialized microenvironment for spermatogonial stem cells to divide, allowing both self-renewal and spermatogenesis. In the present study, we used mice with a conditional activated allele of the beta-catenin gene (Ctnnb1(tm1Mmt)(/+)) in Sertoli cells expressing Cre recombinase driven by the...

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Identifiers

PMID: 19794154
DOI: 10.1095/biolreprod.109.079335
PMCID: PMC2809230

Genes

GDNF
AMH

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