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Article

Regulated Wnt/beta-catenin signaling sustains adult spermatogenesis in mice.

Biology of reproduction - 1 Jan 2014

Kerr Genevieve E, Young Julia C, Horvay Katja, Abud Helen E, Loveland Kate L

Abstract excerpt

The importance of Wnt signaling for postnatal testis function has been previously studied in several mouse models, with chronic pathway disruption addressing its function in Sertoli cells and in postmeiotic germ cells. While chronic beta-catenin deletion in Sertoli cells does not profoundly affect testis development, new data indicate that Wnt signaling is required at multiple stages of spermatogenesis. We used...

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PMID: 24258210
DOI: 10.1095/biolreprod.112.105809

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