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Article

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice.

Behavioural brain research - 1 Aug 2013

Zhang Junfang, Guo Jiejie, Zhao Xin, Chen Zhuoyou, Wang Gang, Liu Aiming, Wang Qinwen, Zhou Wenhua, Xu Ying, Wang Chuang

Abstract excerpt

Memory deficit is a marker of Alzheimer's disease (AD) that has been highly associated with the dysfunction of cyclic GMP (cGMP) signaling and an ongoing inflammatory process. Phosphodiesterase-5 (PDE5) inhibitors prevent the breakdown of cGMP and are currently studied as a possible target for cognitive enhancement. However, it is still unknown whether inhibition of PDE5 reversed β-amyloid peptide (Aβ)-induced...

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PMID: 23685322
DOI: 10.1016/j.bbr.2013.05.017

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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