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Article

An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jul 2009

Ostrovsky Olga, Makarewich Catherine A, Snapp Erik L, Argon Yair

Abstract excerpt

Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER) chaperone for which only few client proteins and no cofactors are known and whose mode of action is unclear. To decipher the mode of GRP94 action in vivo, we exploited our finding that GRP94 is necessary for the production of insulin-like growth factor (IGF)-II and developed a cell-based functional assay. Grp94(-/-) cells are hypersensitive to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19553200
DOI: 10.1073/pnas.0902626106
PMCID: PMC2710619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells.PMID 19553200Read ↗

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