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Article

The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP.

The Journal of biological chemistry - 31 Mar 2006

Lamb Heather K, Mee Christopher, Xu Weiming, Liu Lizhi, Blond Sylvie, Cooper Alan, Charles Ian G, Hawkins Alastair R

Abstract excerpt

GRP78 is a major protein regulated by the mammalian endoplasmic reticulum stress response, and up-regulation has been shown to be important in protecting cells from challenge with cytotoxic agents. GRP78 has ATPase activity, acts as a chaperone, and interacts specifically with other proteins, such as caspases, as part of a mechanism regulating apoptosis. GRP78 is also reported to have a possible role as a Ca2+...

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PMID: 16418174
DOI: 10.1074/jbc.M503964200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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