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Article

Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production.

PloS one - 1 Jan 2013

Zhang Yi, Tseng Chun-Chih, Tsai Yuan-Li, Fu Xiaoyong, Schiff Rachel, Lee Amy S

Abstract excerpt

Traditionally, GRP78 has been regarded as an endoplasmic reticulum (ER) lumenal protein due to its carboxyl KDEL retention motif. Recently, a subfraction of GRP78 is found to localize to the surface of specific cell types, serving as co-receptors and regulating signaling. However, the physiological relevance of cell surface GRP78 (sGRP78) expression in cancer and its functional interactions at the cell surface...

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Identifiers

PMID: 24244613
DOI: 10.1371/journal.pone.0080071
PMCID: PMC3823711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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