Article
Association between a common IL10 distal promoter haplotype and IgE production in individuals with atopic dermatitis.
International journal of immunogenetics - 1 Aug 2009
Lacy K, Archer C, Wood N, Bidwell J
Abstract excerpt
Atopic dermatitis (AD) is a genetically determined inflammatory skin disease characterized by abnormal cytokine production, including increased production of interleukin 10 (IL10). Single nucleotide polymorphisms (SNP) and haplotypes in the IL10 gene promoter region on chromosome 1q31-32 have been implicated in several inflammatory diseases, but generally, only SNPs proximal to the transcription start site (TSS)...
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