A network model for the correlation between epistasis and genomic complexity.

Abstract excerpt

The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is antagonistic on average (mutational effects tend to cancel each other out), whereas a transition towards synergistic epistasis occurs in more complex genomes (mutational...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomics
• Share to Algorithms
• Share to Computational Biology