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Article

Acellular and "low" pertussis vaccines: adverse events and the role of mutations.

Revista do Instituto de Medicina Tropical de Sao Paulo - 1 Jan 2000

Higashi Hisako G, Luna Expedito, Precioso Alexander R, Vilela Marluce, Kubrusly Flávia S, Dias Waldely O, Raw Isaias

Abstract excerpt

OBJECTIVE: to discuss the current PAHO recommendation that does not support the substitution of traditional cellular DTP vaccine by acellular DTP, and the role of mutations, in humans, as the main cause of rare adverse events, such as epileptic-like convulsions, triggered by pertussis vaccine. DATA REVIEW: the main components related to toxic effects of cellular pertussis vaccines are the lipopolysaccharide of...

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PMID: 19551286
DOI: 10.1590/s0036-46652009000300002

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