Article
Modulation of the CD4(+) T cell response after acellular pertussis vaccination in the presence of TLR4 ligation.
Vaccine - 17 Mar 2015
Brummelman Jolanda, Helm Kina, Hamstra Hendrik-Jan, van der Ley Peter, Boog Claire J P, Han Wanda G H, van Els Cécile A C M
Abstract excerpt
Whole cell pertussis (wP) vaccines are gradually being replaced by aluminum salt-adjuvanted acellular pertussis (aP) vaccines. These promote CD4(+) T cell responses with a non-protective Th2 component, while protective immune mechanisms to B. pertussis may rather involve long-lived Th1/Th17 type CD4(+) T cells. Here we asked whether addition of a non-toxic meningococcal LPS derivative, LpxL1, as adjuvant can...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.