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Article

JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis.

Blood - 1 Dec 2007

Barosi Giovanni, Bergamaschi Gaetano, Marchetti Monia, Vannucchi Alessandro M, Guglielmelli Paola, Antonioli Elisabetta, Massa Margherita, Rosti Vittorio, Campanelli Rita, Villani Laura, Viarengo Gianluca, Gattoni Elisabetta, Gerli Giancarla, Specchia Giorgina, Tinelli Carmine, Rambaldi Alessandro, Barbui Tiziano

Abstract excerpt

Few investigators have evaluated the usefulness of the JAK2 V617F mutation for explaining the phenotypic variations and for predicting the risk of major clinical events in primary myelofibrosis (PMF). In a transversal survey we assayed by allele-specific polymerase chain reaction (PCR) the JAK2 V617F mutational status in 304 patients with PMF. Multiple DNA samples were collected prospectively from 64 patients,...

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Share to Amino Acid Substitution
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutation, Missense

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Source

Identifiers

PMID: 17712047
DOI: 10.1182/blood-2007-07-099184

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis.PMID 17712047Read ↗

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