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Article

EZH2 mutational status predicts poor survival in myelofibrosis.

Blood - 10 Nov 2011

Guglielmelli Paola, Biamonte Flavia, Score Joannah, Hidalgo-Curtis Claire, Cervantes Francisco, Maffioli Margherita, Fanelli Tiziana, Ernst Thomas, Winkelman Nils, Jones Amy V, Zoi Katerina, Reiter Andreas, Duncombe Andrew, Villani Laura, Bosi Alberto, Barosi Giovanni, Cross Nicholas C P, Vannucchi Alessandro M

Abstract excerpt

We genotyped 370 subjects with primary myelofibrosis (PMF) and 148 with postpolycythemia vera/postessential thrombocythemia (PPV/PET) MF for mutations of EZH2. Mutational status at diagnosis was correlated with hematologic parameters, clinical manifestations, and outcome. A total of 25 different EZH2 mutations were detected in 5.9% of PMF, 1.2% of PPV-MF, and 9.4% of PET-MF patients; most were exonic heterozygous...

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Share to Enhancer of Zeste Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21921040
DOI: 10.1182/blood-2011-06-363424

Genes

ASXL1
CBL
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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