Article
Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival.
Leukemia - 1 Apr 2008
Tefferi A, Lasho T L, Huang J, Finke C, Mesa R A, Li C Y, Wu W, Hanson C A, Pardanani A
Abstract excerpt
The clinical relevance of JAK2V617F allele burden in primary myelofibrosis (PMF) has not been previously studied. Bone marrow-derived DNA from 199 patients with PMF was subjected to qualitative (n=199) and quantitative (n=129) analysis for V617F. Mutational frequency was 58% and median mutant all...
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