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Article

[Clinical significance of the quantification of JAK2V617F allele burden in classical Ph-negative myeloproliferative neoplasms].

Medicina clinica - 13 Oct 2012

Kerguelén Fuentes Ana Esther, Hernández-Maraver Dolores, Lombardia Luis, Canales Albendea Miguel Angel, Rodriguez de la Rúa Ana

Abstract excerpt

BACKGROUND AND OBJECTIVES: Our study has investigated the presence of the mutation V617F in the JAK2 gene in patients diagnosed with chronic myeloproliferative neoplasms (MPNs). Furthermore, we determined if JAK2 (V617F) allelic burden associates with a specific clinical phenotype and if its quantification can be used as a marker to predict outcome and complications in patients with MPNs. PATIENTS AND METHODS: A...

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Source

Identifiers

PMID: 22743278
DOI: 10.1016/j.medcli.2012.03.032

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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[Clinical significance of the quantification of JAK2V617F allele burden in classical Ph-negative myeloproliferative neoplasms].PMID 22743278Read ↗

[JAK2 V617F mutation burden and its clinical implications in 415 patients with myeloproliferative neoplasm].Semantic proximity Read ↗

Study on the Clinical Significance of JAK2V617F Allele Burden in Philadelphia Chromosome-Negative Myeloproliferative Neoplasm.Semantic proximity Read ↗

The JAK2 V617F allele burden in essential thrombocythemia, polycythemia vera and primary myelofibrosis--impact on disease phenotype.Semantic proximity Read ↗

JAK2 V617F Mutational Burden and Clinical Findings Relationship in Myeloproliferative NeoplasmsSemantic proximity Read ↗

Clinical features and outcomes of JAK2 V617F-positive polycythemia vera and essential thrombocythemia according to the JAK2 V617F allele burdenSemantic proximity Read ↗

JAK2 allele burden is correlated with a risk of venous but not arterial thrombosis.Semantic proximity Read ↗

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JAK2V617F allele burden in patients with myeloproliferative neoplasms.Semantic proximity Read ↗

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Clinical Impact of JAK2V617F Allele Burden in Philadelphia-Negative Myeloproliferative NeoplasmsSemantic proximity Read ↗

Thromboses and hemorrhages are common in MPN patients with high JAK2V617F allele burden.Semantic proximity Read ↗

The JAK2 V617F mutational status and allele burden may be related with the risk of venous thromboembolic events in patients with Philadelphia-negative myeloproliferative neoplasms.Semantic proximity Read ↗

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