Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of gene copy number variation on anesthesia in Drosophila melanogaster.

Anesthesiology - 1 Jul 2009

Alone Debasmita P, Rodriguez Jason C, Noland Cameron L, Nash Howard A

Abstract excerpt

BACKGROUND: Chromosomal deletions and duplications, which result in halving or doubling of copy number in a block of genes, are an important source of variation between individuals. Phenotypic effects of copy number variation are commonly observed, but effects on sensitivity to volatile anesthetics have not been assessed in any organism. METHODS: The potency with which halothane depresses the righting reflex of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthesia
Share to Animals, Genetically Modified
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Gene Dosage

Share to Genetic Variation

Share to Halothane

Source

Open in PubMed Open full text

Identifiers

PMID: 19546691
DOI: 10.1097/ALN.0b013e3181a3276c
PMCID: PMC2701505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of gene copy number variation on anesthesia in Drosophila melanogaster.PMID 19546691Read ↗

Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity.Semantic proximity Read ↗

Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster.Semantic proximity Read ↗

Interplay between copy number, dosage compensation and expression noise in <i>Drosophila</i>Semantic proximity Read ↗

A portrait of copy-number polymorphism in Drosophila melanogaster.Semantic proximity Read ↗

A genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity to halothane.Semantic proximity Read ↗

Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster.Semantic proximity Read ↗

Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans.Semantic proximity Read ↗

Common genetic determinants of halothane and isoflurane potencies in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster.Semantic proximity Read ↗

Use of Drosophila mutants to distinguish among volatile general anesthetics.Semantic proximity Read ↗

A new assay for the genetic study of general anesthesia in Drosophila melanogaster: use in analysis of mutations in the X-chromosomal 12E region.Semantic proximity Read ↗

Genetics of anesthetic response: autosomal mutations that render Drosophila resistant to halothane.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.