Article
Use of Drosophila mutants to distinguish among volatile general anesthetics.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994
Campbell D B, Nash H A
Abstract excerpt
The way general anesthetics cause their clinically useful effects on the nervous system is not known. Since the principal determinant of the potency of these agents is their solubility in oil, the role of chemical structure in affecting anesthetic targets has been obscured. In this work, we use an intense beam of light (Tinklenberg, J. A., Segal, I. S., Tianzhi, G. & Maze, M. (1991) Ann. N.Y. Acad. Sci. 625,...
Topics
- Animals
- Drosophila
- Drug Resistance
- Halothane
- Light
- Male
- Mutation
- Volatilization