Article
Common genetic determinants of halothane and isoflurane potencies in Caenorhabditis elegans.
Anesthesiology - 1 Dec 1998
van Swinderen B, Galifianakis A, Crowder M
Abstract excerpt
BACKGROUND: Genetics provides a way to evaluate anesthetic action simultaneously at the molecular and behavioral levels. Results from strains that differ in anesthetic sensitivity have been mixed in their support of unitary theories of anesthesia. Here the authors use the previously demonstrated large variation of halothane sensitivities in Caenorhabditis elegans recombinant inbred strains to assess the...
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