A genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity to halothane.

doi:10.1073/pnas.87.21.8632

Back to search

Article

A genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity to halothane.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1990

Krishnan K S, Nash H A

Abstract excerpt

In an attempt to identify genes that control or encode the targets of general anesthetics, we have chemically mutagenized fruit flies and selected four lines that show an abnormal response to the volatile anesthetic halothane. Specifically, about 2-fold higher concentrations of halothane are requ...

Topics

Animals
Chromosome Mapping
Dose-Response Relationship, Drug
Drosophila melanogaster
Drug Resistance
Female
Halothane
Mutation
Time Factors
X Chromosome

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.