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Article

A genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity to halothane.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1990

Krishnan K S, Nash H A

Abstract excerpt

In an attempt to identify genes that control or encode the targets of general anesthetics, we have chemically mutagenized fruit flies and selected four lines that show an abnormal response to the volatile anesthetic halothane. Specifically, about 2-fold higher concentrations of halothane are required to induce the loss of motor control in the mutant flies. Fine mapping of two isolates indicates that they alter a...

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Identifiers

PMID: 2122464
DOI: 10.1073/pnas.87.21.8632
PMCID: PMC55011

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A genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity to halothane.PMID 2122464Read ↗

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Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic effects on an anesthetic-sensitive pathway in the brain of Drosophila.Semantic proximity Read ↗

The genetics of response to volatile anesthetics in Caenorhabditis elegans.Semantic proximity Read ↗

Mutations conferring new patterns of sensitivity to volatile anesthetics in Caenorhabditis elegans.Semantic proximity Read ↗

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Zebrafish: A Pharmacogenetic Model for Anesthesia.Semantic proximity Read ↗

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