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Article

Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2.

The Journal of biological chemistry - 4 Sept 2009

Schumann Frank, Hoffmeister Helen, Bader Reto, Schmidt Maren, Witzgall Ralph, Kalbitzer Hans Robert

Abstract excerpt

The PKD1 and PKD2 genes are the genes that are mutated in patients suffering from autosomal dominant polycystic kidney disease. The human PKD2 gene codes for a 968-amino acid long membrane protein called polycystin-2 that represents a cation channel whose activity can be regulated by Ca(2+) ions. By CD, fluorescence, and NMR spectroscopy, we have studied a 117-amino acid-long fragment of the cytoplasmic domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nuclear Magnetic Resonance, Biomolecular

Share to Polycystic Kidney, Autosomal Dominant

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Share to Spectrometry, Fluorescence

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Source

Open in PubMed Open full text

Identifiers

PMID: 19546223
DOI: 10.1074/jbc.M109.025635
PMCID: PMC2782030

Genes

PKD2
PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2.PMID 19546223Read ↗

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