Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Senescent Growth Arrest in Mesenchymal Stem Cells Is Bypassed by Wip1-Mediated Downregulation of Intrinsic Stress Signaling Pathways

14 May 2009

Abstract excerpt

Human mesenchymal stem cells (hMSCs) have been widely studied as a source of primary adult stem cells for cell therapy because of their multidifferentiation potential; however, the growth arrest (also known as "premature senescence") often found in hMSCs cultured in vitro has been a major obstacle to the in-depth characterization of these cells. In addition, the inability to maintain constant cell growth hampers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19544416
DOI: 10.1002/stem.121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Senescent Growth Arrest in Mesenchymal Stem Cells Is Bypassed by Wip1-Mediated Downregulation of Intrinsic Stress Signaling PathwaysPMID 19544416Read ↗

The modulation of the oxidative stress response in chondrocytes by Wip1 and its effect on senescence and dedifferentiation during in vitro expansion.Semantic proximity Read ↗

Expression of the p16INK4A Gene Is Associated Closely with Senescence of Human Mesenchymal Stem Cells and Is Potentially Silenced by DNA Methylation During In Vitro ExpansionSemantic proximity Read ↗

SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterinSemantic proximity Read ↗

Aging alters tissue resident mesenchymal stem cell propertiesSemantic proximity Read ↗

Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts.Semantic proximity Read ↗

The HBP1 Transcriptional Repressor Participates in RAS-Induced Premature SenescenceSemantic proximity Read ↗

The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacitySemantic proximity Read ↗

miR-335 Correlates with Senescence/Aging in Human Mesenchymal Stem Cells and Inhibits Their Therapeutic Actions Through Inhibition of AP-1 ActivitySemantic proximity Read ↗

H 2 O 2 Accumulation Mediates Differentiation Capacity Alteration, But Not Proliferative Decline, in Senescent Human Fetal Mesenchymal Stem CellsSemantic proximity Read ↗

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and CancerSemantic proximity Read ↗

Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromesSemantic proximity Read ↗

In Vitro Senescence of Rat Mesenchymal Stem Cells is Accompanied by Downregulation of Stemness-Related and DNA Damage Repair GenesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.