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Article

p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2009

Tu Shui Ping, Chi Alfred L, Ai Walden, Takaishi Shigeo, Dubeykovskaya Zina, Quante Michael, Fox James G, Wang Timothy C

Abstract excerpt

Overexpression of trefoil factor 2 (TFF2) is associated with increased cell migration, resistance to apoptosis, and possibly increased gastric cancer invasion. Dysregulation of p53 is frequently observed in preneoplastic conditions of the stomach. Here, we investigated the effect of p53 on the expression and function of TFF2 in gastric cancer cell lines. Gene expression was determined by reverse...

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Source

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Identifiers

PMID: 19541923
DOI: 10.1152/ajpgi.90620.2008
PMCID: PMC2724087

Genes

TFF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.PMID 19541923Read ↗

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