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Article

Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2007

Tu Shuiping, Chi Alfred L, Lim Seonhee, Cui Guanglin, Dubeykovskaya Zina, Ai Wandong, Fleming John V, Takaishi Shigeo, Wang Timothy C

Abstract excerpt

Trefoil family factor 2 (TFF2) is expressed in gastrointestinal epithelial cells where it serves to maintain mucosal integrity and promote epithelial repair. The peptide hormone, gastrin, stimulates acid secretion but also induces proliferation of the acid-secreting mucosa. Because the relationship between these peptides of overlapping function is not understood, we chose to investigate the regulatory effect of...

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Identifiers

PMID: 17332476
DOI: 10.1152/ajpgi.00348.2006

Genes

TFF2
EGFR
CCK
INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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