Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways.

Gastroenterology - 1 May 2006

Yio Xianyang, Diamond Matthew, Zhang Jie-Yu, Weinstein Harel, Wang Lu-Hai, Werther Lawrence, Itzkowitz Steven

Abstract excerpt

BACKGROUND & AIMS: Trefoil factor family-1 (TFF1) is a key gastric tumor-suppressor gene. TFF1 knockout mice develop multiple gastric adenomas and carcinomas, and human gastric cancers typically lack TFF1 expression. Recently, TFF1 mutations have been found in human gastric cancer. The purpose of this study was to determine the functionality of these mutants. METHODS: Recombinant wild-type TFF1 and the gastric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Invasiveness

Share to Sampling Studies

Share to Sensitivity and Specificity

Share to Stomach Neoplasms

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 16697734
DOI: 10.1053/j.gastro.2006.01.040

Genes

TFF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways.PMID 16697734Read ↗

Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomasSemantic proximity Read ↗

Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancerSemantic proximity Read ↗

Somatic mutations of the trefoil factor family 1 gene in gastric cancer.Semantic proximity Read ↗

The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosisSemantic proximity Read ↗

Trefoil factor 1 elevates the malignant phenotype of mucinous ovarian cancer cell through Wnt/β-catenin signaling.Semantic proximity Read ↗

miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cellsSemantic proximity Read ↗

Expression of TFF1, TFF2 and TFF3 in gastric cancerSemantic proximity Read ↗

A functional polymorphism in TFF1 promoter is associated with the risk and prognosis of gastric cancer.Semantic proximity Read ↗

Decreased Expression of Gastrokine 1 and the Trefoil Factor Interacting Protein TFIZ1/GKN2 in Gastric Cancer: Influence of Tumor Histology and Relationship to PrognosisSemantic proximity Read ↗

The cell-penetrating FOXM1 N-terminus (M1-138) demonstrates potent inhibitory effects on cancer cells by targeting FOXM1 and FOXM1-interacting factor SMAD3Semantic proximity Read ↗

Trefoil factor 1 gene alternations and expression in colorectal carcinomas.Semantic proximity Read ↗

The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.