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Article

Silencing miR-202-3p increases MMP-1 and promotes a brain invasive phenotype in metastatic breast cancer cells.

PloS one - 1 Jan 2020

Harati Rania, Hafezi Shirin, Mabondzo Aloïse, Tlili Abdelaziz

Abstract excerpt

BACKGROUND: Brain metastasis (BM) is a major cause of morbidity and mortality in breast cancer (BC) and its molecular mechanism remains poorly understood. Transmigration of metastatic cells through the brain endothelium is an essential step in BM. Metalloproteinase-1 (MMP-1) overexpression plays a key role in promoting trans-endothelial migration by degrading the inter-endothelial junctions and disrupting the...

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Identifiers

PMID: 33002044
DOI: 10.1371/journal.pone.0239292
PMCID: PMC7529272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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