Article
Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions.
Toxicology and applied pharmacology - 1 Sept 2009
Valenzuela Olga L, Drobná Zuzana, Hernández-Castellanos Erika, Sánchez-Peña Luz C, García-Vargas Gonzalo G, Borja-Aburto Víctor H, Stýblo Miroslav, Del Razo Luz M
Abstract excerpt
Exposure to naturally occurring inorganic arsenic (iAs), primarily from contaminated drinking water, is considered one of the top environmental health threats worldwide. Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the biotransformation pathway of iAs. AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to trivalent arsenicals, resulting in the production of...
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