Association Between Variants in Arsenic (+3 Oxidation State) Methyltranserase (AS3MT) and Urinary Metabolites of Inorganic Arsenic: Role of Exposure Level.

doi:10.1093/toxsci/kfw112

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Article

Association Between Variants in Arsenic (+3 Oxidation State) Methyltranserase (AS3MT) and Urinary Metabolites of Inorganic Arsenic: Role of Exposure Level.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2016

Xu Xiaofan, Drobná Zuzana, Voruganti V Saroja, Barron Keri, González-Horta Carmen, Sánchez-Ramírez Blanca, Ballinas-Casarrubias Lourdes, Cerón Roberto Hernández, Morales Damián Viniegra, Terrazas Francisco A Baeza, Ishida María C, Gutiérrez-Torres Daniela S, Saunders R Jesse, Crandell Jamie, Fry Rebecca C, Loomis Dana, García-Vargas Gonzalo G, Del Razo Luz M, Stýblo Miroslav, Mendez Michelle A

Abstract excerpt

Variants in AS3MT, the gene encoding arsenic (+3 oxidation state) methyltranserase, have been shown to influence patterns of inorganic arsenic (iAs) metabolism. Several studies have suggested that capacity to metabolize iAs may vary depending on levels of iAs exposure. However, it is not known whether the influence of variants in AS3MT on iAs metabolism also vary by level of exposure. We investigated, in a...

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PMID: 27370415
DOI: 10.1093/toxsci/kfw112
PMCID: PMC5808745

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