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Polymorphisms of the AS3MT gene are associated with arsenic methylation capacity and damage to the P21 gene in arsenic trioxide plant workers.

Toxicology and industrial health - 1 Dec 2021

Ni Guanghui, Tan Jingwen, Wang Mengjie, Ping Nina, Liu Min, He Yuefeng

Abstract excerpt

Epidemiological evidence suggests that the metabolic profiles of each individual exposed to arsenic (As) are related to the risk of cancer, coronary heart disease, and diabetes. The arsenite methyltransferase (AS3MT) gene plays a key role in As metabolism. Several single nucleotide polymorphisms in the AS3MT gene may affect both enzyme activity and gene transcription. AS3MT polymorphisms are associated with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34730462
DOI: 10.1177/07482337211013321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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