[Establishment of a multiplex ligation-dependent SNP genotyping method and its application in the detection of genes related to chemotherapeutic drugs in breast cancer].

Abstract excerpt

OBJECTIVE: To establish a method for SNP genotyping of multi-genes by allele-specific oligonucleotide probe ligation mediated by a thermostable ligase, and to explore the genetic polymorphisms of drug-metabolizing enzymes in breast cancer patients and their association with chemotherapeutic responses. METHODS: 10 SNP loci of enzyme genes related to chemotherapeutic drugs such as taxanes, anthracyclines and...

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