Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High IL-17E and Low IL-17C Dermal Expression Identifies a Fibrosis-Specific Motif Common to Morphea and Systemic Sclerosis

19 Aug 2014

Abstract excerpt

BACKGROUND: High interleukin (IL)-17A levels are characteristically found in the skin of systemic sclerosis (SSc) individuals. Our aim was to investigate whether the dermal expression of IL-17A and related IL-17 family members (i.e. IL-17C, IL-17E and IL-17F) could distinguish fibrotic from healthy skin and could show similarities in SSc and morphea, two disorders with presumed distinct pathogenesis, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Psoriasis: Treatment and Pathogenesis
Share to Skin Diseases and Diabetes
Share to Systemic Sclerosis and Related Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25136988
DOI: 10.1371/journal.pone.0105008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High IL-17E and Low IL-17C Dermal Expression Identifies a Fibrosis-Specific Motif Common to Morphea and Systemic SclerosisPMID 25136988Read ↗

IL-17 in the Pathogenesis of Disease: Good Intentions Gone AwrySemantic proximity Read ↗

IL-17 Ligand and Receptor Family Members Are Differentially Expressed by Keratinocyte Subpopulations and Modulate Their Differentiation and Inflammatory PhenotypeSemantic proximity Read ↗

The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.Semantic proximity Read ↗

Pathogenic Roles of Autoantibodies and Aberrant Epigenetic Regulation of Immune and Connective Tissue Cells in the Tissue Fibrosis of Patients with Systemic SclerosisSemantic proximity Read ↗

IL-17A Dissociates Inflammation from Fibrogenesis in Systemic SclerosisSemantic proximity Read ↗

Sex-biased Fibroblast Subpopulations and Transcriptional Programs Reveal Mechanisms of Skin Lesion Development in Systemic SclerosisSemantic proximity Read ↗

The roles of interleukin (IL)-17A and IL-17F in hidradenitis suppurativa pathogenesis: evidence from human in vitro preclinical experiments and clinical samplesSemantic proximity Read ↗

Interleukin-17 Cytokines and Receptors: Potential Amplifiers of Tendon InflammationSemantic proximity Read ↗

Understanding the Role of Epithelial Cells in the Pathogenesis of Systemic SclerosisSemantic proximity Read ↗

The role of selected cytokines from the interleukin 1 family in the pathophysiology of morphea.Semantic proximity Read ↗

Expression of interleukin (IL)-1 family members upon stimulation with IL-17 differs in keratinocytes derived from patients with psoriasis and healthy donorsSemantic proximity Read ↗

A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect ItSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.