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Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy

16 Jun 2009

Abstract excerpt

BACKGROUND: Epigenetic silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) by promoter methylation is associated with improved survival in glioblastomas treated with alkylating agents. In this study, we investigated MGMT promoter methylation in glioblastomas treated with temozolomide and radiotherapy in a single UK treatment centre. METHODS: Quantitative methylation data at individual CpG sites were...

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PMID: 19536096
DOI: 10.1038/sj.bjc.6605127

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