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Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma

1 Oct 2011

Abstract excerpt

OBJECTIVES: 1) To correlate the methylation status of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter to its gene and protein expression levels in glioblastoma and 2) to determine the most reliable method for using MGMT to predict the response to adjuvant therapy in patients with glioblastoma. BACKGROUND: The MGMT gene is epigenetically silenced by promoter hypermethylation in gliomas, and this...

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PMID: 22012047
DOI: 10.1590/s1807-59322011001000013

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