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Article

Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas.

Neuro-oncology - 1 Aug 2009

Everhard Sibille, Tost Jörg, El Abdalaoui Hafida, Crinière Emmanuelle, Busato Florence, Marie Yannick, Gut Ivo G, Sanson Marc, Mokhtari Karima, Laigle-Donadey Florence, Hoang-Xuan Khê, Delattre Jean-Yves, Thillet Joëlle

Abstract excerpt

The O(6)-methylguanine-DNA methyltransferase gene (MGMT) is methylated in several cancers, including gliomas. However, the functional role of cysteine-phosphate-guanine (CpG) island (CGI) methylation in MGMT silencing is still controversial. The aim of this study was to investigate whether MGMT CGI methylation correlates inversely with RNA expression of MGMT in glioblastomas and to determine the CpG region whose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19224763
DOI: 10.1215/15228517-2009-001
PMCID: PMC2743215

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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